Environmental factors can significantly affect disease prevalence, including neuropsychiatric disorders such as depression. The ratio of deuterium to protium in water shows substantial geographical variation, which could affect disease susceptibility. Thus the link between deuterium content of water and depression was investigated, both epidemiologically, and in a mouse model of chronic mild stress. We performed a correlation analysis between deuterium content of tap water and rates of depression in regions of the USA. Next, we used a 10-day chronic stress paradigm to test whether 2-week deuteriumdepleted
water treatment (91 ppm) affects depressive-like behavior and hippocampal SERT. The effect of deuterium-depletion on sleep electrophysiology was also evaluated in naïve mice. There was a geographic correlation between a content of deuterium and the prevalence of depression across the USA.
In the chronic stress model, depressive-like features were reduced in mice fed with deuterium-depleted water, and SERT expression was decreased in mice treated with deuterium-treated water compared with regular water. Five days of predator stress also suppressed proliferation in the dentate gyrus; this effect was attenuated in mice fed with deuterium-depleted water. Finally, in naïve mice, deuteriumdepleted water treatment increased EEG indices of wakefulness, and decreased duration of REM sleep, phenomena that have been shown to result from the administration of selective serotonin reuptake
inhibitors (SSRI). Our data suggest that the deuterium content of water may influence the incidence of affective disorder-related pathophysiology and major depression, which might be mediated by theserotoninergic mechanisms.
Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND
license.
DDW-and depression
WANT TO FIND OUT MORE ABOUTÂ DEUTERIUM-DEPLETED WATER? SEE WHAT OTHER READERS ASKED. GO TO FAQ SECTION >Â Â HERE
Thinking of trying deuterium-depleted water? See options HERE
Disclaimer: Hydro-Health DDW and Extralightwater.com products did not influence the design, conduct, analysis, and interpretation of the studies cited in this website.
Medical Disclaimer (read more HERE) : This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Eurogator LLC nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program. Statements made on this website have not been evaluated by the U.S. Food and Drug Administration. Products sold on this website are not intended to diagnose, treat, cure, or prevent any disease.
HYDRO HEALTH DDW TAGS: deuetrium-depleted water usa, deuterium-depleted water hydro health, deuterium-depleted water for cancer, deuterium-depleted water and disease, deuterium-depleted water and immune disease, deuterium-depleted water diabetes, best ddw, ddw producers usa, ddw health, deuterium content in ddw, deuterium levels in water, ddw science, ddw research, hydro health good, ddw good?, ddw effects, ddw benefits, deuterium depleted water benefits
